Venture capital firm
Two Sigma Ventures portfolio
twosigmaventures.comTwo Sigma Ventures is a venture capital firm based in New York, United States. It has invested in 60 venture-backed companies across 94 funding rounds on VCMC, and led 17 of those rounds. 2 of them were in the last 12 months.
60
Venture-backed companies
in its portfolio on VCMC
94
Funding rounds
led 17
2
Last 12 months
rounds, Oct 2025 to Sep 2026
17
With a disclosed valuation
of 60 companies
$80.0B
Combined value of its private companies
the whole companies, not what Two Sigma Ventures owns
57 private companies Two Sigma Ventures has backed have a VCMC valuation; together they are worth $80.0B. That is the value of the whole companies, not what Two Sigma Ventures owns. Etched is 27% of the total. 3 companies it backed have since been acquired and are not included. How VCMC values companies.
Values cover private companies only; public companies are not included.
Portfolio
Two Sigma Ventures' most valuable portfolio companies
The 10 most valuable private companies Two Sigma Ventures has backed, by VCMC's valuation. Values cover private companies only; public companies are not included.
- 1 Etched Electronical Components Manufacturing, San Jose $21.4B range $18.3B – $26.6B Joined at Series A, 2024
- 2 Xaira Therapeutics Biotechnology, South San Francisco $15.2B range $4.9B – $23.1B Joined at Growth, 2024
- 3 WHOOP Medical Supply Manufacturers, Boston $12.1B range $8.8B – $15.9B Led at Series B, 2015
- 4 Remote Tech Companies $6.9B range $2.9B – $8.0B Joined at Series A, 2020
- 5 Socure Tech Companies, Incline Village $5.3B range $4.5B – $6.7B Joined at Series B, 2017
- 6 Enveda Biotechnology, Boulder $2.0B range $1.7B – $3.0B Joined at Series A, 2021
- 7 Tech Companies, New York $1.8B range $901M – $2.6B Joined at Series A, 2020
- 8 RapidSOS Tech Companies, New York $1.3B range $869M – $1.5B Joined at Series A, 2017
- 9 Tech Companies, New York $1.2B range $98.7M – $1.5B Joined at Series B, 2016
- 10 insitro Biotechnology, South San Francisco $1.1B range $195M – $5.8B Joined at Series B, 2020
Portfolio
Full Two Sigma Ventures portfolio (60 companies)
60 companies. Load more shows the rest.
| # | Last round | History | Range | Trend | Grade | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Etched Electronical Components Manufacturing · since Series A, 2024 | Growth Equity Aug 2026 $700M | $21.4B | $18.3B – $26.6B | $23.1B (+8%) | $2.1B | 0% | – | growing | A | |
| 2 | Xaira Therapeutics Biotechnology · since Growth, 2024 | Growth Equity Apr 2024 $1.00B | $15.2B | $4.9B – $23.1B | $9.1B (-40%) | $1.4B | 0% | 212 | up | C | |
| 3 | WHOOP Medical Supply Manufacturers · led at Series B, 2015 | Series G Mar 2026 $575M | $12.1B | $8.8B – $15.9B | $13.8B (+14%) | $1.5B | 0% | 1,649 | growing | A | |
| 4 | Socure Tech Companies · since Series B, 2017 | Growth Equity Aug 2026 $156M | $5.3B | $4.5B – $6.7B | $5.8B (+10%) | $524M | 0% | 690 | growing | A | |
| 5 | Enveda Biotechnology · since Series A, 2021 | Series E Sep 2026 $311M | $2.0B | $1.7B – $3.0B | $2.6B (+27%) | $286M | 0% | 381 | up | A | |
| 6 | Carbon Health Health Care Services · since Series B, 2019 | Series D Jan 2023 $100M | $1.1B | $139M – $2.3B | $914M (-14%) | $172M | 22% | 1,078 | flat | D | |
| 7 | insitro Biotechnology · since Series B, 2020 | Series C Mar 2021 $400M | $1.1B | $195M – $5.8B | $1.0B (-10%) | $497M | 59% | 257 | flat | D | |
| 8 | RapidSOS Tech Companies · since Series A, 2017 | Series D Nov 2025 $100M | $1.3B | $869M – $1.5B | $1.3B (+2%) | $148M | 0% | 326 | up | A | |
| 9 | Remote Tech Companies · since Series A, 2020 | Series C Apr 2022 $300M | $6.9B | $2.9B – $8.0B | $6.9B (0%) | $762M | 0% | 19,027 | growing | B | |
| 10 | Kallyope Biotechnology · since Series B, 2018 | Series D Feb 2022 $236M | $236M | $93.0M – $1.8B | $223M (-6%) | $169M | 97% | 54 | down | D | |
| 11 | Tech Companies · since Series B, 2016 | Series E Mar 2021 $180M | $1.2B | $98.7M – $1.5B | $1.1B (-2%) | $178M | 0% | 592 | flat | D | |
| 12 | Tech Companies · since Series A, 2020 | Series E Mar 2025 $126M | $1.8B | $901M – $2.6B | $1.7B (-4%) | $208M | 14% | 219 | up | B | |
| 13 | Tech Companies · since Series A, 2019 | Series C Feb 2022 $110M | $120M | $71.4M – $376M | $111M (-8%) | $118M | 97% | 41 | shrinking | C | |
| 14 | Tech Companies · led at Series B, 2026 | Series B Feb 2026 $70M | $695M | $369M – $1.1B | $786M (+13%) | $86.5M | 0% | 123 | up | B | |
| 15 | Tech Companies · since Series D, 2018 | Series D May 2018 $125M | $174M | $46.7M – $699M | $174M (0%) | $104M | 65% | 16 | down | D | |
| 16 | Tech Companies · led at Seed, 2020 | Series B Sep 2022 $50M | $47.8M | $26.6M – $125M | $33.0M (-31%) | $42.7M | 97% | 31 | shrinking | C | |
| 17 | Tech Companies · since Seed, 2018 | Series B Nov 2021 $50M | $174M | $15.8M – $396M | $166M (-4%) | $39.4M | 26% | 102 | flat | D | |
| 18 | Tech Companies · led at Series B, 2024 | Series B Jun 2024 $27M | $140M | $63.2M – $182M | $120M (-14%) | $17.9M | 19% | 65 | up | B | |
| 19 | Tech Companies · since Series B, 2025 | Series B Jul 2025 $35M | $480M | $235M – $681M | $480M (0%) | $52.8M | 0% | 148 | growing | B | |
| 20 | Tech Companies · since Series C, 2014 | Series D May 2018 $23M | $200M | $18.9M – $414M | $200M (0%) | $41.1M | 21% | 20 | flat | D | |
| 21 | Tech Companies · since Series A, 2021 | Series B Nov 2024 $10M | $72.3M | $26.4M – $168M | $56.9M (-21%) | $11.5M | 97% | 70 | shrinking | C | |
| 22 | Tech Companies · since Series A, 2022 | Series A Jan 2022 $15M | $23.6M | $4.40M – $121M | $22.3M (-5%) | $16.1M | 68% | 14 | down | D | |
| 23 | Tech Companies · since Series A, 2021 | Series A Mar 2021 $10M | $57.0M | $6.46M – $138M | $53.0M (-7%) | $16.7M | 28% | 39 | up | D | |
| 24 | Tech Companies · led at Series A, 2024 | Series A Mar 2024 $10M | $30.4M | $13.6M – $113M | $21.4M (-30%) | $12.8M | 97% | 31 | down | D | |
| 25 | Tech Companies · since Series A, 2018 | Acquisition Jul 2021 | $77.3M acquired 2021 | $7.80M – $110M | – | – | 0% | 36 | flat | D | |
| 26 | Tech Companies · since Seed, 2025 | Seed Sep 2025 $7.8M | $85.6M | $30.3M – $121M | $85.6M (0%) | $15.4M | 0% | 36 | growing | C | |
| 27 | Tech Companies · led at Seed, 2020 | Seed Dec 2020 $5.0M | $22.2M | $2.50M – $78.3M | $22.6M (+2%) | $13.7M | 47% | 20 | flat | D | |
| 28 | Tech Companies · since Series A, 2014 | Series A May 2014 $5.0M | $14.3M | $1.81M – $39.2M | $14.3M (0%) | $7.00M | 38% | 12 | flat | D | |
| 29 | Tech Companies · since Seed, 2024 | Seed Sep 2024 $4.0M | $16.6M | $9.84M – $30.6M | $8.87M (-46%) | $10.5M | 97% | 6 | shrinking | B | |
| 30 | Tech Companies · led at Seed, 2021 | Seed May 2021 $3.3M | $34.0M | $2.30M – $64.6M | $32.4M (-5%) | $9.19M | 7% | 18 | up | D | |
| 31 | Biotechnology · since Growth, 2021 | Series C Oct 2026 $62M | $564M | $370M – $1.1B | $733M (+30%) | $80.6M | 0% | 76 | flat | B | |
| 32 | Software Development Services · since Series A, 2017 | Series D Sep 2024 $90M | $861M | $297M – $1.4B | $589M (-32%) | $117M | 35% | 60 | unknown | C | |
| 33 | Tech Companies · led at Series A, 2020 | Other Jan 2026 $20M | $505M | $231M – $769M | $505M (0%) | $55.6M | 0% | 298 | up | C | |
| 34 | Data Solutions · since Series B, 2015 | Series C Sep 2018 $95M | $181M | $30.0M – $416M | $181M (0%) | $57.2M | 37% | 142 | flat | D | |
| 35 | Metal Fabrication Services · led at Growth, 2023 | Series B Feb 2026 $67M | $645M | $326M – $1.1B | $743M (+15%) | $81.8M | 0% | 68 | up | C | |
| 36 | Tech Companies · since Seed, 2018 | Series B Sep 2023 $100M | $168M | $116M – $338M | $114M (-32%) | $79.3M | 97% | 80 | shrinking | B | |
| 37 | Loans & Financing · led at Series A, 2021 | Debt Oct 2022 $100M | $95.9M | $23.3M – $173M | $95.9M (0%) | $20.8M | 0% | 97 | growing | D | |
| 38 | Biotechnology · led at Series B, 2024 | Series C Aug 2025 $44M | $529M | $279M – $751M | $529M (0%) | $58.2M | 0% | 57 | up | B | |
| 39 | Biotechnology · since Series A, 2022 | Series A Nov 2022 $96M | $90.0M | $45.0M – $332M | $61.0M (-32%) | $134M | 97% | 27 | shrinking | C | |
| 40 | Insurance - Agents, Carriers & Brokers · led at Series C, 2025 | Series C Apr 2025 $30M | $491M | $298M – $564M | $491M (0%) | $54.0M | 0% | 202 | up | B | |
| 41 | Tech Companies · led at Series B, 2020 | Series C Jul 2021 $50M | $52.9M | $25.2M – $193M | $47.5M (-10%) | $51.8M | 97% | 28 | shrinking | D | |
| 42 | Software Development Services · since Series B, 2020 | Series C Feb 2022 $55M | $405M | $164M – $712M | $401M (-1%) | $68.1M | 21% | 248 | growing | C | |
| 43 | Tech Companies · led at Series A, 2023 | Series B Sep 2025 $54M | $497M | $232M – $707M | $485M (-2%) | $56.6M | 8% | 137 | flat | B | |
| 44 | Biotechnology · since Series A, 2021 | Series A Dec 2021 $68M | $86.6M | $23.7M – $871M | $86.0M (-1%) | $114M | 92% | 21 | down | D | |
| 45 | Tech Companies · since Series A, 2018 | Series C Jun 2022 $30M | $290M | $41.0M – $480M | $273M (-6%) | $40.7M | 0% | 145 | up | D | |
| 46 | Biotechnology · since Series A, 2022 | Series A Feb 2022 $60M | $572M | $40.5M – $1.1B | $544M (-5%) | $109M | 0% | 143 | up | D | |
| 47 | Tech Companies · led at Series B, 2018 | Acquisition Dec 2024 | $36.1M acquired 2024 | $17.2M – $130M | – | – | 97% | 50 | shrinking | D | |
| 48 | Tech Companies · led at Series A, 2020 | Series B Jul 2021 $45M | $303M | $27.5M – $375M | $287M (-5%) | $41.3M | 0% | 311 | up | D | |
| 49 | Tech Companies · since Series B, 2020 | Series C Jun 2022 $30M | $259M | $27.9M – $500M | $230M (-11%) | $47.3M | 19% | 262 | flat | D | |
| 50 | Biotechnology · since Series A, 2024 | Series A Oct 2024 $43M | $506M | $127M – $770M | $340M (-33%) | $70.9M | 0% | 21 | up | C |
Valuation: VCMC's valuation with its range, from a low to a high scenario; a company with no valuation shows a dash, one acquired after its last round its last value as a private company.
Activity
How Two Sigma Ventures invests: stages, industries and countries
Most of its rounds are Series A (35%). Its companies span 14 industries, most in Tech Companies, Biotechnology and Insurance - Agents, Carriers & Brokers, across 4 countries.
Rounds by stage
- Seed 9
- Series A 33
- Series B 29
- Series C and later 23
Investments by industry
- Tech Companies 35
- Biotechnology 10
- Insurance - Agents, Carriers & Brokers 3
- Software Development Services 2
- Alarms, Surveillance & Security Systems 1
- Banks & ATMs 1
- Data Solutions 1
- Electronical Components Manufacturing 1
Investments by country
- United States 57
- Mexico 1
- Singapore 1
- United Kingdom 1
Recent rounds
Two Sigma Ventures' latest investments
Two Sigma Ventures' most recent funding rounds, newest first. 2 rounds in the last 12 months.
- Series B $67M 19 Feb 2026
- Series B, led $70M 4 Feb 2026
- Seed $7.8M 17 Sep 2025
- Series A $30M 8 Sep 2025
- Series C $44M 12 Aug 2025
- Series B $35M 14 Jul 2025
- Series C, led $30M 23 Apr 2025
- Series B $13M 1 Mar 2025
- Series C $40M 23 Jan 2025
- Series A $43M 8 Oct 2024
Co-investors
Two Sigma Ventures' top co-investors
The investors that most often join the same rounds as Two Sigma Ventures. Lux Capital leads, with 8 rounds together.
- Lux Capital 8 rounds together
- 6 rounds together
- 6 rounds together
- 6 rounds together
- 6 rounds together
- 6 rounds together
- Sequoia Capital 5 rounds together
- Andreessen Horowitz 5 rounds together
- GV 5 rounds together
- 4 rounds together
About
About Two Sigma Ventures
Two Sigma Investments, LP, known as Two Sigma Ventures, is an American venture capital firm engaged in early-stage investments in data science and engineering-driven companies. The firm supports startups across sectors such as infrastructure tools, healthcare, real estate, consumer hardware, enterprise SaaS, fintech, techbio, consumer tech, crypto, and decentralized finance. Two Sigma Ventures provides funding and long-term partnerships, with a focus on software engineering, data science, quantitative modeling, and machine learning.
Description from Veridion's company data.
- Based in
- New York, United States
- Team
- 8 people, -69% in a year
- Type
- Venture capital firm
Focus markets
- Healthcare
- Real Estate
- Consumer Hardware
- Infrastructure
- Enterprise SaaS
- Fintech
- Technology
- Crypto
- Decentralized Finance
What Two Sigma Ventures offers
- Early-Stage Venture Capital Investment
- Data Science and Engineering Consulting
- Quantitative Modeling and Machine Learning Advisory
- Industry-Specific Technology Investment
- Enterprise SaaS Company Investment
- Fintech Company Investment
- Healthcare Technology Investment
- Real Estate Technology Investment
Questions
Two Sigma Ventures: frequently asked questions
How many companies has Two Sigma Ventures invested in?
60 venture-backed companies on VCMC, across 94 funding rounds.
What are Two Sigma Ventures' most valuable private companies?
Etched ($21.4B), Xaira Therapeutics ($15.2B), WHOOP ($12.1B), by VCMC's valuation.
What was Two Sigma Ventures' latest investment?
Freeform, a Series B round in Feb 2026 of $67M.
Which stages does Two Sigma Ventures invest in?
Two Sigma Ventures invests most often at Series A (33 rounds), followed by Series B (29) and Series C and later (23). It has also joined 9 seed rounds.
What is Two Sigma Ventures' portfolio worth?
Its private companies with a VCMC valuation are worth $80.0B together. That is the sum of the companies' values, not what Two Sigma Ventures owns.
Who does Two Sigma Ventures invest alongside?
Lux Capital (8 rounds), Trilogy Equity Partners (6 rounds), Casdin Capital (6 rounds).